Cell motility

Project information

The cell model is constructed to account for the overall cell dynamics based on the interactions between cytoskeletal fibres and focal adhesions. It is composed of branches and nodes that form a hierarchical tree like structure meant to represent the mechanical structure of the cell by emulating its centre (nucleus), membrane protrusions, adhesions and mechanosensors.

This cell model is ultimately intended to be used to address tissue morphogenesis. Hence it has been designed to comply to four constraints: (1) capture the dynamical aspects of the mechanical interaction of the cell with its environment; (2) easily parameterized to adapt to different cell types; (3) generalizable in 3D; (4) fast enough to integrate many interacting cells.